Querying the database
The myticalin database includes a manually curated collection of the nucleotide and protein sequences of myticalins, a family of linear cationic antimicrobial peptides displaying strong gill-specificity first described in marine mussels (Mytilus spp.) by Leoni and colleagues in 2017. The collection derives from the combined analysis of genomic and transcriptomic information from multiple species belonging to the Mytilus complex (Mytilus galloprovincialis, Mytilus edulis, Mytilus trossulus and Mytilus chilensis), and their congeners Mytilus californianus and Mytilus coruscus. The sequences are currently classified within five major subfamilies (A, B, C, D and E) based on strict phylogenetic criteria and their amino acid composition.
Please, choose a search parameter and use the autocomplete function for querying the database (read the notes * below):
search by antimicrobial peptide name [A3, B1, C2, D3, etc]
search by antimicrobial peptide class [A, B, C, D, E]
search by antimicrobial peptide amino acid sequence (100% match only)
search by lineage [Mytilus species complex, Mytilus californianus - Mytilus coruscus]
* Although myticalins A1, A2, A6, A7, A10, C5, D1 and D6 were originally reported by Leoni and colleagues (2017) thanks to the detection of an expressed mRNA sequence, we could not validate their existence at genomic level, since no complete matching gene sequence was identified in any of the available genome assemblies available to date. Therefore, the reliability of this sequence should be considered questionable until further confirmation.